Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles

• Main Authors: Shenghua Gao (Author), Letian Song (Author), Yusen Cheng (Author), Fabao Zhao (Author), Dongwei Kang (Author), Shu Song (Author), Mianling Yang (Author), Bing Ye (Author), Wei Zhao (Author), Yajie Tang (Author), Erik De Clercq (Author), Christophe Pannecouque (Author), Peng Zhan (Author), Xinyong Liu (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Indolylarylsulfones (IASs) are classical HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with a unique scaffold and possess potent antiviral activity. To address the high cytotoxicity and improve safety profiles of IASs, we introduced various sulfonamide groups linked by alkyl diamine...