Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis

• Príomhchruthaitheoirí: Yong Chen (Údar), Yuhki Koike (Údar), Lijun Chi (Údar), Abdalla Ahmed (Údar), Hiromu Miyake (Údar), Bo Li (Údar), Carol Lee (Údar), Paul Delgado-Olguín (Údar), Agostino Pierro (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: The Company of Biologists, 2019-12-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Major risk factors for necrotizing enterocolitis (NEC) are formula feeding and prematurity; however, their pathogenic mechanisms are unknown. Here, we found that insufficient arginine/nitric oxide synthesis limits blood flow in the intestinal microvasculature, leading to hypoxia, mucosal damage and...