Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis

• Main Authors: Yong Chen (Author), Yuhki Koike (Author), Lijun Chi (Author), Abdalla Ahmed (Author), Hiromu Miyake (Author), Bo Li (Author), Carol Lee (Author), Paul Delgado-Olguín (Author), Agostino Pierro (Author)
• Format: Book
• Published: The Company of Biologists, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Major risk factors for necrotizing enterocolitis (NEC) are formula feeding and prematurity; however, their pathogenic mechanisms are unknown. Here, we found that insufficient arginine/nitric oxide synthesis limits blood flow in the intestinal microvasculature, leading to hypoxia, mucosal damage and...