Preliminary Assessment of Intramuscular Depot of Lipid-Based Decoquinate Formulation for Long-Term Chemoprophylaxis of Malaria

• Main Authors: Yinzhou Fan (Author), Li Qin (Author), Zhenping Huang (Author), Shuanghong Liang (Author), Xiaoyi Huang (Author), Sumei Zeng (Author), Yucheng Liu (Author), Hongxing Wang (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sustained-release formulations of decoquinate were evaluated for the long-term prophylaxis of malaria. In the initial experiment, mice were protected from liver-stage <i>Plasmodium</i> infection by intramuscular administration of a lipids-based formulation at a dose of decoquinate 200 mg...