Synthesis and Evaluation of Thiol-Conjugated Poloxamer and Its Pharmaceutical Applications

• Main Authors: Muhammad Zaman (Author), Sadaf Saeed (Author), Rabia Imtiaz Bajwa (Author), Muhammad Shafeeq Ur Rahman (Author), Saeed Ur Rahman (Author), Muhammad Jamshaid (Author), Muhammad F. Rasool (Author), Abdul Majeed (Author), Imran Imran (Author), Faleh Alqahtani (Author), Sultan Alshehri (Author), Abdullah F. AlAsmari (Author), Nemat Ali (Author), Mohammed S. Alasmari (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The current study was designed to convert the poloxamer (PLX) into thiolated poloxamer (TPLX), followed by its physicochemical, biocompatibilities studies, and applications as a pharmaceutical excipient in the development of tacrolimus (TCM)-containing compressed tablets. Thiolation was accomplished...