Optimizing extrusion processes and understanding conformational changes in itraconazole amorphous solid dispersions using in-line UV-Vis spectroscopy and QbD principles

• Hoofdauteurs: Hetvi Triboandas (Auteur), Mariana Bezerra (Auteur), Juan Almeida (Auteur), Matheus de Castro (Auteur), Bianca Aloise Maneira Corrêa Santos (Auteur), Walkiria Schlindwein (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2024-12-01T00:00:00Z.
• Onderwerpen: article
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This paper presents a comprehensive investigation of the manufacturing of itraconazole (ITZ) amorphous solid dispersions (ASDs) with Kolllidon® VA64 (KVA64) using hot-melt extrusion (HME) and in-line process monitoring, employing a Quality by Design (QbD) approach. A sequential Design of Experiments...