Super-Resolution Microscopy Reveals an Altered Fibrin Network in Cirrhosis: The Key Role of Oxidative Stress in Fibrinogen Structural Modifications

• Main Authors: Matteo Becatti (Author), Amanda Mannucci (Author), Flavia Rita Argento (Author), Stefano Gitto (Author), Francesco Vizzutti (Author), Fabio Marra (Author), Niccolò Taddei (Author), Claudia Fiorillo (Author), Giacomo Laffi (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cirrhotic patients show a reduced synthesis of both pro- and anti-coagulant factors. Recent reports indicate that they are characterized by a higher risk of thrombotic rather than hemorrhagic complications, but the mechanisms conferring this risk are not fully elucidated. Oxidative-mediated fibrinog...