Novel Antioxidant, Deethylated Ethoxyquin, Protects against Carbon Tetrachloride Induced Hepatotoxicity in Rats by Inhibiting NLRP3 Inflammasome Activation and Apoptosis

• Main Authors: Igor Y. Iskusnykh (Author), Evgenii D. Kryl'skii (Author), Darya A. Brazhnikova (Author), Tatyana N. Popova (Author), Khidmet S. Shikhaliev (Author), Konstantin K. Shulgin (Author), Larisa V. Matasova (Author), Sergey S. Popov (Author), Dmitry A. Zhaglin (Author), Anastasia A. Zakharova (Author), Nelli R. Popova (Author), Nikolai Fattakhov (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation and an increase in antioxidant responses mediated by oxidative stress play an important role in the pathogenesis of acute liver injury (ALI). We utilized in silico prediction of biological activity spectra for substances (PASS) analysis to estimate the potential biological activity prof...