Cover Image

Chrysophanol-8-O-glucoside protects mice against acute liver injury by inhibiting autophagy in hepatic stellate cells and inflammatory response in liver-resident macrophages

Acute liver failure (ALF) is an unfavorable condition characterized by the rapid loss of liver function and high mortality. Chrysophanol-8-O-glucoside (CPOG) is an anthraquinone derivative isolated from rhubarb. This study aims to evaluate the protective effect of CPOG on lipopolysaccharide (LPS)/D-...

Full description

Saved in:

Bibliographic Details
Main Authors:	Tao Wang (Author), Zhuo Lu (Author), Xin-Hui Qu (Author), Zi-Ying Xiong (Author), Ya-Ting Wu (Author), Yong Luo (Author), Zi-Yu Zhang (Author), Xiao-Jian Han (Author), Cai-Feng Xie (Author)
Format:	Book
Published:	Frontiers Media S.A., 2022-09-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

BCATc inhibitor 2 ameliorated mitochondrial dysfunction and apoptosis in oleic acid-induced non-alcoholic fatty liver disease model
by: Zhuo Lu, et al.
Published: (2022)

Chrysophanol-8-O-glucoside, an Anthraquinone Derivative in Rhubarb, Has Antiplatelet and Anticoagulant Activities
by: Eun Ji Seo, et al.
Published: (2012)

Disulfiram inhibits liver fibrosis in rats by suppressing hepatic stellate cell activation and viability
by: Xiao-Mei Yang, et al.
Published: (2022)

DNA Methylation of PTGIS Enhances Hepatic Stellate Cells Activation and Liver Fibrogenesis
by: Xue-yin Pan, et al.
Published: (2018)

The mechanisms of natural products for eye disorders by targeting mitochondrial dysfunction
by: Gui-Feng Sun, et al.
Published: (2024)

Effectiveness of prophylactic antibacterial drugs for patients with liver cirrhosis and upper gastrointestinal bleeding: a systematic review and meta-analysis
by: Zhuo Wang, et al.
Published: (2024)

miR-185 Inhibits Fibrogenic Activation of Hepatic Stellate Cells and Prevents Liver Fibrosis
by: Li Zhou, et al.
Published: (2018)

Infectious disease control: from health security strengthening to health systems improvement at global level
by: Xiao-Xi Zhang, et al.
Published: (2023)

Luteolin Alleviates Liver Fibrosis in Rat Hepatic Stellate Cell HSC-T6: A Proteomic Analysis
by: Batudeligen, et al.
Published: (2023)

Epigallocatechin Gallate During Dietary Restriction - Potential Mechanisms of Enhanced Liver Injury
by: Zhuo Shi, et al.
Published: (2021)

Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis
by: Chan-Yen Kuo, et al.
Published: (2020)

The role of hepatic stellate cells in fibrotic liver diseases
by: Hye Jin Cho, et al.
Published: (2020)

FibroBox: a novel noninvasive tool for predicting significant liver fibrosis and cirrhosis in HBV infected patients
by: Xiao-Jie Lu, et al.
Published: (2020)

2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside induces autophagy of liver by activating PI3K/Akt and Erk pathway in prediabetic rats
by: Xuanbin Wang, et al.
Published: (2020)

Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis
by: Shiyun Pu, et al.
Published: (2021)

Germacrone Attenuates Hepatic Stellate Cells Activation and Liver Fibrosis via Regulating Multiple Signaling Pathways
by: Zhiyong Li, et al.
Published: (2021)

Salvianolic acid B inhibits autophagy and activation of hepatic stellate cells induced by TGF-β1 by downregulating the MAPK pathway
by: Na Jiang, et al.
Published: (2022)

A Cell-Based Metabonomics Approach to Investigate the Varied Influences of Chrysophanol-8-O-β-D-Glucoside With Different Concentrations on L-02 Cells
by: Meichen Liu, et al.
Published: (2019)

NPAS2 Contributes to Liver Fibrosis by Direct Transcriptional Activation of Hes1 in Hepatic Stellate Cells
by: Tao Yang, et al.
Published: (2019)

MicroRNA-125b Promotes Hepatic Stellate Cell Activation and Liver Fibrosis by Activating RhoA Signaling
by: Kai You, et al.
Published: (2018)

Mori Fructus Polysaccharides Attenuate Alcohol-Induced Liver Damage by Regulating Fatty Acid Synthesis, Degradation and Glycerophospholipid Metabolism in Mice
by: Liang Bian, et al.
Published: (2021)

Susceptibility-Related Factor and Biomarkers of Dietary Supplement Polygonum multiflorum-Induced Liver Injury in Rats
by: Can Tu, et al.
Published: (2019)

Baseline lymphocyte and cholinesterase levels may be the predictors of chronic herbal drug-induced liver injury
by: Zhan Zeng, et al.
Published: (2022)

Development of a self-management behaviour scale for liver cirrhosis
by: Qian Wang, et al.
Published: (2015)

Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways
by: Linli Yang, et al.
Published: (2020)

Bile Acids and Liver Cancer: Molecular Mechanism and Therapeutic Prospects
by: Xuemei Zhang, et al.
Published: (2024)

Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation
by: Jing Lu, et al.
Published: (2019)

Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway
by: Xiu AY, et al.
Published: (2021)

SNS-032 attenuates liver fibrosis by anti-active hepatic stellate cells via inhibition of cyclin dependent kinase 9
by: Xiao-Li He, et al.
Published: (2022)

Integrative multi-omics analysis depicts the methylome and hydroxymethylome in recurrent bladder cancers and identifies biomarkers for predicting PD-L1 expression
by: Zhen-Duo Shi, et al.
Published: (2023)

Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats
by: Chen Xiaorong, et al.
Published: (2012)

Desmoplastic small round cell tumor of the liver: diagnosing a rare case on liver biopsy
by: Xiao Feng, et al.
Published: (2023)

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway
by: Mu M, et al.
Published: (2018)

miR-455-3p Alleviates Hepatic Stellate Cell Activation and Liver Fibrosis by Suppressing HSF1 Expression
by: Song Wei, et al.
Published: (2019)

The Role of Autophagy in Liver Cancer: Crosstalk in Signaling Pathways and Potential Therapeutic Targets
by: Jianzhou Cui, et al.
Published: (2020)

Prevalence and causes of cesarean births among women residing at high altitude in Lhasa, Tibet: A retrospective observational study of 7365 women
by: Yuan-Yuan Zheng, et al.
Published: (2019)

Individualized antibiotic dosage regimens for patients with augmented renal clearance
by: A-Xi Shi, et al.
Published: (2023)

The Role of Bone Morphogenetic Protein 9 in Nonalcoholic Fatty Liver Disease in Mice
by: Qin-Juan Sun, et al.
Published: (2021)

Autoimmunity associates with severity of illness in elderly patients with drug-induced liver injury
by: Yu-Ting Xiong, et al.
Published: (2023)

Macrophages in Liver Disease
Published: (2020)