Systemic inhibition of 5-lipoxygenase by MK-886 exacerbates apical periodontitis bone loss in a mouse model

• Hauptverfasser: Igor Bassi Ferreira Petean (Verfasst von), Alice Corrêa Silva-Sousa (Verfasst von), Raquel Assed Bezerra da Silva (Verfasst von), Marília Pacífico Lucisano (Verfasst von), Léa Assed Bezerra da Silva (Verfasst von), Guilherme Piedade Assed de Castro (Verfasst von), Manoel Damião Sousa-Neto (Verfasst von), Lúcia Helena Faccioli (Verfasst von), Francisco Wanderley Garcia Paula-Silva (Verfasst von)
• Format: Buch
• Veröffentlicht: BMC, 2023-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Background To investigate if 5-LO selective inhibitor (MK-886) could be used for systemic treatment of experimentally induced apical periodontitis in a mouse model. Methods Twenty-four C57BL/6 mice were used. After coronal opening, a solution containing Escherichia coli LPS (1.0 µg/µL) was...