Systemic inhibition of 5-lipoxygenase by MK-886 exacerbates apical periodontitis bone loss in a mouse model

• Main Authors: Igor Bassi Ferreira Petean (Author), Alice Corrêa Silva-Sousa (Author), Raquel Assed Bezerra da Silva (Author), Marília Pacífico Lucisano (Author), Léa Assed Bezerra da Silva (Author), Guilherme Piedade Assed de Castro (Author), Manoel Damião Sousa-Neto (Author), Lúcia Helena Faccioli (Author), Francisco Wanderley Garcia Paula-Silva (Author)
• Format: Book
• Published: BMC, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background To investigate if 5-LO selective inhibitor (MK-886) could be used for systemic treatment of experimentally induced apical periodontitis in a mouse model. Methods Twenty-four C57BL/6 mice were used. After coronal opening, a solution containing Escherichia coli LPS (1.0 µg/µL) was...