Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Hauptverfasser: Qian Zhou (VerfasserIn), Meiling Le (VerfasserIn), Yiyi Yang (VerfasserIn), Wenjuan Wang (VerfasserIn), Yuqi Huang (VerfasserIn), Quan Wang (VerfasserIn), Yijing Tian (VerfasserIn), Meiyan Jiang (VerfasserIn), Yong Rao (VerfasserIn), Hai-Bin Luo (VerfasserIn), Yinuo Wu (VerfasserIn)
• Format: Buch
• Veröffentlicht: Elsevier, 2023-03-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...