Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Main Authors: Qian Zhou (Author), Meiling Le (Author), Yiyi Yang (Author), Wenjuan Wang (Author), Yuqi Huang (Author), Quan Wang (Author), Yijing Tian (Author), Meiyan Jiang (Author), Yong Rao (Author), Hai-Bin Luo (Author), Yinuo Wu (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...