Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• المؤلفون الرئيسيون: Qian Zhou (مؤلف), Meiling Le (مؤلف), Yiyi Yang (مؤلف), Wenjuan Wang (مؤلف), Yuqi Huang (مؤلف), Quan Wang (مؤلف), Yijing Tian (مؤلف), Meiyan Jiang (مؤلف), Yong Rao (مؤلف), Hai-Bin Luo (مؤلف), Yinuo Wu (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2023-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...