Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Hauptverfasser: Qian Zhou (Verfasst von), Meiling Le (Verfasst von), Yiyi Yang (Verfasst von), Wenjuan Wang (Verfasst von), Yuqi Huang (Verfasst von), Quan Wang (Verfasst von), Yijing Tian (Verfasst von), Meiyan Jiang (Verfasst von), Yong Rao (Verfasst von), Hai-Bin Luo (Verfasst von), Yinuo Wu (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2023-03-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...