Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Κύριοι συγγραφείς: Qian Zhou (Συγγραφέας), Meiling Le (Συγγραφέας), Yiyi Yang (Συγγραφέας), Wenjuan Wang (Συγγραφέας), Yuqi Huang (Συγγραφέας), Quan Wang (Συγγραφέας), Yijing Tian (Συγγραφέας), Meiyan Jiang (Συγγραφέας), Yong Rao (Συγγραφέας), Hai-Bin Luo (Συγγραφέας), Yinuo Wu (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2023-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...