Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Autores principales: Qian Zhou (Autor), Meiling Le (Autor), Yiyi Yang (Autor), Wenjuan Wang (Autor), Yuqi Huang (Autor), Quan Wang (Autor), Yijing Tian (Autor), Meiyan Jiang (Autor), Yong Rao (Autor), Hai-Bin Luo (Autor), Yinuo Wu (Autor)
• Formato: Libro
• Publicado: Elsevier, 2023-03-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...