Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Egile Nagusiak: Qian Zhou (Egilea), Meiling Le (Egilea), Yiyi Yang (Egilea), Wenjuan Wang (Egilea), Yuqi Huang (Egilea), Quan Wang (Egilea), Yijing Tian (Egilea), Meiyan Jiang (Egilea), Yong Rao (Egilea), Hai-Bin Luo (Egilea), Yinuo Wu (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2023-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...