Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Päätekijät: Qian Zhou (Tekijä), Meiling Le (Tekijä), Yiyi Yang (Tekijä), Wenjuan Wang (Tekijä), Yuqi Huang (Tekijä), Quan Wang (Tekijä), Yijing Tian (Tekijä), Meiyan Jiang (Tekijä), Yong Rao (Tekijä), Hai-Bin Luo (Tekijä), Yinuo Wu (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2023-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...