Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Príomhchruthaitheoirí: Qian Zhou (Údar), Meiling Le (Údar), Yiyi Yang (Údar), Wenjuan Wang (Údar), Yuqi Huang (Údar), Quan Wang (Údar), Yijing Tian (Údar), Meiyan Jiang (Údar), Yong Rao (Údar), Hai-Bin Luo (Údar), Yinuo Wu (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Elsevier, 2023-03-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...