Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Autori principali: Qian Zhou (Autore), Meiling Le (Autore), Yiyi Yang (Autore), Wenjuan Wang (Autore), Yuqi Huang (Autore), Quan Wang (Autore), Yijing Tian (Autore), Meiyan Jiang (Autore), Yong Rao (Autore), Hai-Bin Luo (Autore), Yinuo Wu (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2023-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...