Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• 主要な著者: Qian Zhou (著者), Meiling Le (著者), Yiyi Yang (著者), Wenjuan Wang (著者), Yuqi Huang (著者), Quan Wang (著者), Yijing Tian (著者), Meiyan Jiang (著者), Yong Rao (著者), Hai-Bin Luo (著者), Yinuo Wu (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2023-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...