Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Үндсэн зохиолчид: Qian Zhou (Зохиогч), Meiling Le (Зохиогч), Yiyi Yang (Зохиогч), Wenjuan Wang (Зохиогч), Yuqi Huang (Зохиогч), Quan Wang (Зохиогч), Yijing Tian (Зохиогч), Meiyan Jiang (Зохиогч), Yong Rao (Зохиогч), Hai-Bin Luo (Зохиогч), Yinuo Wu (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2023-03-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...