Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis

• Главные авторы: Qian Zhou (Автор), Meiling Le (Автор), Yiyi Yang (Автор), Wenjuan Wang (Автор), Yuqi Huang (Автор), Quan Wang (Автор), Yijing Tian (Автор), Meiyan Jiang (Автор), Yong Rao (Автор), Hai-Bin Luo (Автор), Yinuo Wu (Автор)
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• Опубликовано: Elsevier, 2023-03-01T00:00:00Z.
• Предметы: article
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Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is highly involved in the development of VaD. In order to verify the therapeutic potential of PDE1 inhibitors against VaD, the...