Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign.

• Asıl Yazarlar: Melissa L Sykes (Yazar), Jonathan B Baell (Yazar), Marcel Kaiser (Yazar), Eric Chatelain (Yazar), Sarah R Moawad (Yazar), Danny Ganame (Yazar), Jean-Robert Ioset (Yazar), Vicky M Avery (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Drugs available for the treatment of HAT have significant issues related to difficult administration regimes and limited efficacy across species and disease...