Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign.

• Main Authors: Melissa L Sykes (Author), Jonathan B Baell (Author), Marcel Kaiser (Author), Eric Chatelain (Author), Sarah R Moawad (Author), Danny Ganame (Author), Jean-Robert Ioset (Author), Vicky M Avery (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Drugs available for the treatment of HAT have significant issues related to difficult administration regimes and limited efficacy across species and disease...