Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign.

• 主要な著者: Melissa L Sykes (著者), Jonathan B Baell (著者), Marcel Kaiser (著者), Eric Chatelain (著者), Sarah R Moawad (著者), Danny Ganame (著者), Jean-Robert Ioset (著者), Vicky M Avery (著者)
• フォーマット: 図書
• 出版事項: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Drugs available for the treatment of HAT have significant issues related to difficult administration regimes and limited efficacy across species and disease...