Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling

• Main Authors: Min Chen (Author), Eric A. Wilson (Author), Zhenzhong Cui (Author), Hui Sun (Author), Yogendra B. Shrestha (Author), Brandon Podyma (Author), Christina H. Le (Author), Benedetta Naglieri (Author), Karel Pacak (Author), Oksana Gavrilova (Author), Lee S. Weinstein (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Gsα couples multiple receptors, including the melanocortin 4 receptor (MC4R), to intracellular cAMP generation. Germline inactivating Gsα mutations lead to obesity in humans and mice. Mice with brain-specific Gsα deficiency also develop obesity with reduced energy expenditure and locomoto...