Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection.

• Main Authors: Martin C Taylor (Author), Alexander Ward (Author), Francisco Olmo (Author), Shiromani Jayawardhana (Author), Amanda F Francisco (Author), Michael D Lewis (Author), John M Kelly (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Investigations into intracellular replication and differentiation of Trypanosoma cruzi within the mammalian host have been restricted by limitations in our ability to detect parasitized cells throughout the course of infection. We have overcome this problem by generating genetically modified parasit...