Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System

• Egile Nagusiak: Weipeng Hong (Egilea), Peiheng Cai (Egilea), Chuncao Xu (Egilea), Di Cao (Egilea), Weibang Yu (Egilea), Zhongxiang Zhao (Egilea), Min Huang (Egilea), Jing Jin (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The pentose phosphate pathway (PPP), which branches from glycolysis, is correlated with cancer cell proliferation, survival and senescence. In this study, differences in the metabolic profile of the PPP and the redox status of human lung carcinoma A549 cells and cisplatin-induced multidrug-resistant...