Bortezomib modulates CHIT1 and YKL40 in monocyte-derived osteoclast and in myeloma cells

• Main Authors: Tibullo eDaniele (Author), Michelino eDi Rosa (Author), Cesarina eGiallongo (Author), Piera eLa Cava (Author), Nunziatina L Parrinello (Author), Alessandra eRomano (Author), Concetta eConticello (Author), Maria V. Brundo (Author), Salvatore eSaccone (Author), Lucia eMalaguarnera (Author), Francesco eDi Raimondo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteolytic bone disease is a common manifestation of multiple myeloma (MM) that leads to progressive skeleton destruction and is the most severe cause of morbidity in MM patients.It results from increased osteolytic activity and decrease osteoblastic function. Activation of mammalian chitinases CHIT...