HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice

• Main Authors: Raian E. Contreras (Author), Tim Gruber (Author), Ismael González-García (Author), Sonja C. Schriever (Author), Meri De Angelis (Author), Noemi Mallet (Author), Miriam Bernecker (Author), Beata Legutko (Author), Dhiraj Kabra (Author), Mathias Schmidt (Author), Matthias H. Tschöp (Author), Ruth Gutierrez-Aguilar (Author), Jane Mellor (Author), Cristina García-Cáceres (Author), Paul T. Pfluger (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With age, metabolic perturbations accumulate to elevate our obesity burden. While age-onset obesity is mostly driven by a sedentary lifestyle and high calorie intake, genetic and epigenetic factors also play a role. Among these, members of the large histone deacetylase (HDAC) family are of particula...