Bacteria-Targeted Clindamycin Loaded Polymeric Nanoparticles: Effect of Surface Charge on Nanoparticle Adhesion to MRSA, Antibacterial Activity, and Wound Healing

• Main Authors: Nurhasni Hasan (Author), Jiafu Cao (Author), Juho Lee (Author), Shwe Phyu Hlaing (Author), Murtada A. Oshi (Author), Muhammad Naeem (Author), Min-Hyo Ki (Author), Bok Luel Lee (Author), Yunjin Jung (Author), Jin-Wook Yoo (Author)
• Format: Book
• Published: MDPI AG, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adhesion of nanoparticles (NPs) to the bacterial cell wall by modifying their physicochemical properties can improve the antibacterial activity of antibiotic. In this study, we prepared positively charged clindamycin-loaded poly (lactic-co-glycolic acid)-polyethylenimine (PLGA-PEI) nanoparticles (Cl...