Apoptosis-Inducing Factor Deficiency Induces Tissue-Specific Alterations in Autophagy: Insights from a Preclinical Model of Mitochondrial Disease and Exercise Training Effects

• Hauptverfasser: Sara Laine-Menéndez (Verfasst von), Miguel Fernández-de la Torre (Verfasst von), Carmen Fiuza-Luces (Verfasst von), Aitor Delmiro (Verfasst von), Joaquín Arenas (Verfasst von), Miguel Ángel Martín (Verfasst von), Patricia Boya (Verfasst von), Alejandro Lucia (Verfasst von), María Morán (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2022-03-01T00:00:00Z.
• Schlagworte: article
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We analyzed the effects of apoptosis-inducing factor (AIF) deficiency, as well as those of an exercise training intervention on autophagy across tissues (heart, skeletal muscle, cerebellum and brain), that are primarily affected by mitochondrial diseases, using a preclinical model of these condition...