Apoptosis-Inducing Factor Deficiency Induces Tissue-Specific Alterations in Autophagy: Insights from a Preclinical Model of Mitochondrial Disease and Exercise Training Effects

• Main Authors: Sara Laine-Menéndez (Author), Miguel Fernández-de la Torre (Author), Carmen Fiuza-Luces (Author), Aitor Delmiro (Author), Joaquín Arenas (Author), Miguel Ángel Martín (Author), Patricia Boya (Author), Alejandro Lucia (Author), María Morán (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We analyzed the effects of apoptosis-inducing factor (AIF) deficiency, as well as those of an exercise training intervention on autophagy across tissues (heart, skeletal muscle, cerebellum and brain), that are primarily affected by mitochondrial diseases, using a preclinical model of these condition...