Lipidated dengue-2 envelope protein domain III independently stimulates long-lasting neutralizing antibodies and reduces the risk of antibody-dependent enhancement.

• Main Authors: Chen-Yi Chiang (Author), Chien-Hsiung Pan (Author), Chun-Hsiang Hsieh (Author), Jy-Ping Tsai (Author), Mei-Yu Chen (Author), Hsueh-Hung Liu (Author), Shih-Jen Liu (Author), Pele Chong (Author), Chih-Hsiang Leng (Author), Hsin-Wei Chen (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Dengue virus is a mosquito-transmitted virus that can cause self-limiting dengue fever, severe life-threatening dengue hemorrhagic fever and dengue shock syndrome. The existence of four serotypes of dengue virus has complicated the development of an effective and safe dengue vaccine. Rec...