TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis.

• Main Authors: Bethany Brunton (Author), Kai Rogers (Author), Elisabeth K Phillips (Author), Rachel B Brouillette (Author), Ruayda Bouls (Author), Noah S Butler (Author), Wendy Maury (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>T cell immunoglobulin mucin domain-1 (TIM-1) is a phosphatidylserine (PS) receptor, mediating filovirus entry into cells through interactions with PS on virions. TIM-1 expression has been implicated in Ebola virus (EBOV) pathogenesis; however, it remains unclear whethe...