A novel GAA-repeat-expansion-based mouse model of Friedreich's ataxia

• Main Authors: Sara Anjomani Virmouni (Author), Vahid Ezzatizadeh (Author), Chiranjeevi Sandi (Author), Madhavi Sandi (Author), Sahar Al-Mahdawi (Author), Yogesh Chutake (Author), Mark A. Pook (Author)
• Format: Book
• Published: The Company of Biologists, 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by a GAA repeat expansion mutation within intron 1 of the FXN gene, resulting in reduced levels of frataxin protein. We have previously reported the generation of human FXN yeast artificial chromosome (YAC) t...