Multivariate Independent Component Analysis Identifies Patients in Newborn Screening Equally to Adjusted Reference Ranges

• Main Authors: Štěpán Kouřil (Author), Julie de Sousa (Author), Kamila Fačevicová (Author), Alžběta Gardlo (Author), Christoph Muehlmann (Author), Klaus Nordhausen (Author), David Friedecký (Author), Tomáš Adam (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Newborn screening (NBS) of inborn errors of metabolism (IEMs) is based on the reference ranges established on a healthy newborn population using quantile statistics of molar concentrations of biomarkers and their ratios. The aim of this paper is to investigate whether multivariate independent compon...