The oral IRAK4 inhibitors zabedosertib and BAY1830839 suppress local and systemic immune responses in a randomized trial in healthy male volunteers

Abstract This study evaluated and characterized the pharmacological activity of the orally administered interleukin‐1 receptor‐associated kinase 4 (IRAK4) inhibitors BAY1834845 (zabedosertib) and BAY1830839 in healthy male volunteers. Participants received one of either IRAK4 inhibitors or a control...

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Váldodahkkit: Stefan J. Jodl (Dahkki), Wouter tenVoorde (Dahkki), Stefan Klein (Dahkki), Andrea Wagenfeld (Dahkki), Frank S. Zollmann (Dahkki), Maximilian Feldmüller (Dahkki), Naomi B. Klarenbeek (Dahkki), Digna T. deBruin (Dahkki), Manon A. A. Jansen (Dahkki), Robert Rissmann (Dahkki), Beate Rohde (Dahkki), Matthijs Moerland (Dahkki)
Materiálatiipa: Girji
Almmustuhtton: Wiley, 2024-03-01T00:00:00Z.
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