Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer

• Main Authors: Fei Yu (Author), Weidan Tan (Author), Zhiquan Chen (Author), Xiaoju Shen (Author), Xiaoxiang Mo (Author), Xiaocheng Mo (Author), Jingchuan He (Author), Zhihua Deng (Author), Jie Wang (Author), Zhuo Luo (Author), Jie Yang (Author)
• Format: Book
• Published: BMC, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background As the increasing mortality and incidence of lung cancer (LC), there is an urgent need to discover novel treatment agent. In this study, we aimed to investigate the anti-LC effects of nitidine chloride (NC), a small molecular compound extracted from Chinese herbal medicine, while...