Characterization of Transverse Aortic Constriction in Mice Based on the Specific Recruitment of Leukocytes to the Hypertrophic Myocardium and the Aorta Ascendens

• Main Authors: Jan Lukas Kleiner (Author), Odilia Köpke (Author), Anton Faron (Author), Yunyang Zhang (Author), Jan Cornelssen (Author), Mark Coburn (Author), Stilla Frede (Author), Lars Eichhorn (Author), Christina Katharina Weisheit (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transverse aortic constriction (TAC) is a model that mimics pressure overload-induced left ventricular (LV) hypertrophy in mice. Alterations in immune cell functionality can promote cardiac and vascular remodeling. In the present study, we characterized the time course in innate immune cell dynamics...