PSORS1C1 Hypomethylation Is Associated with Allopurinol-Induced Severe Cutaneous Adverse Reactions during Disease Onset Period: A Multicenter Retrospective Case-Control Clinical Study in Han Chinese

• Main Authors: Bao Sun (Author), Lin Cheng (Author), Yan Xiong (Author), Lei Hu (Author), Zhiying Luo (Author), Maosong Zhou (Author), Ji Li (Author), Hongfu Xie (Author), Fazhong He (Author), Xiaoqing Yuan (Author), Xiaoping Chen (Author), Hong-Hao Zhou (Author), Zhaoqian Liu (Author), Xiang Chen (Author), Wei Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Allopurinol-induced severe cutaneous adverse reactions (SCARs), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are life-threatening autoimmune reactions. Evidence is growing that epigenetic variation...