MicroRNA-134-5p Regulates Media Degeneration through Inhibiting VSMC Phenotypic Switch and Migration in Thoracic Aortic Dissection

• Main Authors: Ying Wang (Author), Chang-Qing Dong (Author), Guang-Yin Peng (Author), Hao-yue Huang (Author), Yun-sheng Yu (Author), Zhen-Chun Ji (Author), Zhen-Ya Shen (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abnormal phenotypic switch, migration, and proliferation of vascular smooth muscle cells (VSMCs) are hallmarks for pathogenesis of thoracic aortic dissection (TAD). In the current study, we identified miR-134-5p as a critical regulator controlling human VSMC phenotypic switch and migration to invest...