Artesunate Combined With Metformin Ameliorate on Diabetes-Induced Xerostomia by Mitigating Superior Salivatory Nucleus and Salivary Glands Injury in Type 2 Diabetic Rats via the PI3K/AKT Pathway

• Main Authors: Siqin Zhang (Author), Jiarui Li (Author), Xiaolin Nong (Author), Yuxiang Zhan (Author), Jiazhi Xu (Author), Danni Zhao (Author), Chubin Ma (Author), Yuchen Wang (Author), Yixing Li (Author), Zhan Li (Author), Jiaquan Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polydipsia and xerostomia are the most common complications that seriously affect oral health in patients with diabetes. However, to date, there is no effective treatment for diabetic xerostomia. Recent studies have reported that artesunate (ART) and metformin (Met) improve salivary gland (SG) hypof...