ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation

• Main Authors: Jacqueline Stöckli (Author), Armella Zadoorian (Author), Kristen C. Cooke (Author), Vinita Deshpande (Author), Belinda Yau (Author), Gaia Herrmann (Author), Melkam A. Kebede (Author), Sean J. Humphrey (Author), David E. James (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Insulin suppresses adipose tissue lipolysis after a meal, playing a key role in metabolic homeostasis. This is mediated via the kinase Akt and its substrate phosphodiesterase 3B (PDE3B). Once phosphorylated and activated, PDE3B hydrolyses cAMP leading to the inactivation of cAMP-dependent...