Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance

• Main Authors: Mar Quiñones (Author), Omar Al-Massadi (Author), Rosalía Gallego (Author), Johan Fernø (Author), Carlos Diéguez (Author), Miguel López (Author), Ruben Nogueiras (Author)
• Format: Book
• Published: Elsevier, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucagon receptor antagonists and humanized glucagon antibodies are currently studied as promising therapies for obesity and type II diabetes. Among its variety of actions, glucagon reduces food intake, but the molecular mechanisms mediating this effect as well as glucagon resistance are...