Resveratrol antagonizes thyroid hormone-induced expression of checkpoint and proliferative genes in oral cancer cells

• Main Authors: Chia-Cheng Lin (Author), Yu-Tang Chin (Author), Ya-Jung Shih (Author), Yi-Ru Chen (Author), Yao-Yu Chung (Author), Chi-Yu Lin (Author), Chao-Nan Hsiung (Author), Jacqueline Whang-Peng (Author), Sheng-Yang Lee (Author), Hung-Yun Lin (Author), Paul J. Davis (Author), Kuan Wang (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/purpose: Dysregulation of cell cycle checkpoint control may lead to the independence of growth regulating signals. Checkpoint protein such as the PD-1/PD-L1 immune checkpoint involving tumor cells and host immune defense lymphocytes is a well-studied therapeutic target in oncology. Acting...