Esterase-Responsive Polyglycerol-Based Nanogels for Intracellular Drug Delivery in Rare Gastrointestinal Stromal Tumors

• 主要な著者: Sebastian Schötz (著者), Adele K. Griepe (著者), Björn B. Goerisch (著者), Sally Kortam (著者), Yael Shammai Vainer (著者), Mathias Dimde (著者), Hanna Koeppe (著者), Stefanie Wedepohl (著者), Elisa Quaas (著者), Katharina Achazi (著者), Avi Schroeder (著者), Rainer Haag (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2023-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Rare gastrointestinal stromal tumors (GISTs) are caused by mutations in the KIT and PDGFRA genes. Avapritinib (BLU-285) is a targeted selective inhibitor for mutated KIT and PDGFRA receptors that can be used to treat these tumors. However, there are subtypes of GISTs that exhibit resistance against...