Phenotype versus genotype to optimize cancer dosing in the clinical setting-focus on 5‐fluorouracil and tyrosine kinase inhibitors

• Główni autorzy: Jennifer H. Martin (Autor), Peter Galettis (Autor), Alex Flynn (Autor), Jennifer Schneider (Autor)
• Format: Książka
• Wydane: Wiley, 2024-04-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract Cancer medicines often have narrow therapeutic windows; toxicity can be severe and sometimes fatal, but inadequate dose intensity reduces efficacy and survival. Determining the optimal dose for each patient is difficult, with body‐surface area used most commonly for chemotherapy and flat do...