Bioinformatics and In Vitro Studies Reveal the Importance of p53, PPARG and Notch Signaling Pathway in Inhibition of Breast Cancer Stem Cells by Hesperetin

• Main Authors: Adam Hermawan (Author), Muthi Ikawati (Author), Annisa Khumaira (Author), Herwandhani Putri (Author), Riris Istighfari Jenie (Author), Sonia Meta Angraini (Author), Haruma Anggraini Muflikhasari (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The failure of chemotherapy in breast cancer is caused by breast cancer stem cells (BCSCs), a minor population of cells in bulk mammary tumors. Previously, hesperetin, a citrus flavonoid, showed cytotoxicity in several cancer cells and increased cytotoxicity of doxorubicin and cisplatin. He...