Targeting of PDGF-C/NRP-1 autocrine loop as a new strategy for counteracting the invasiveness of melanoma resistant to braf inhibitors

• Main Authors: Federica Ruffini (Author), Claudia Ceci (Author), Maria Grazia Atzori (Author), Simona Caporali (Author), Lauretta Levati (Author), Laura Bonmassar (Author), Gian Carlo Antonini Cappellini (Author), Stefania D'Atri (Author), Grazia Graziani (Author), Pedro Miguel Lacal (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melanoma resistance to BRAF inhibitors (BRAFi) is often accompanied by a switch from a proliferative to an invasive phenotype. Therefore, the identification of signaling molecules involved in the development of metastatic properties by resistant melanoma cells is of primary importance. We have previ...