Endoglin (CD105) Silencing Mediated by shRNA Under the Control of Endothelin-1 Promoter for Targeted Gene Therapy of Melanoma

• Main Authors: Natasa Tesic (Author), Urska Kamensek (Author), Gregor Sersa (Author), Simona Kranjc (Author), Monika Stimac (Author), Ursa Lampreht (Author), Veronique Preat (Author), Gaelle Vandermeulen (Author), Miha Butinar (Author), Boris Turk (Author), Maja Cemazar (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endoglin (CD105), a transforming growth factor (TGF)-β coreceptor, and endothelin-1, a vasoconstrictor peptide, are both overexpressed in tumor endothelial and melanoma cells. Their targeting is therefore a promising therapeutic approach for melanoma tumors. The aim of our study was to construct a e...