Lung-Targeted Delivery of Dimethyl Fumarate Promotes the Reversal of Age-Dependent Established Lung Fibrosis

• Main Authors: Kosuke Kato (Author), Ioannis Papageorgiou (Author), Yoon-Joo Shin (Author), Jennifer M. Kleinhenz (Author), Sunny Palumbo (Author), Seongmin Hahn (Author), Joseph D. Irish (Author), Skye P. Rounseville (Author), Kenneth S. Knox (Author), Louise Hecker (Author)
• 格式: 图书
• 出版: MDPI AG, 2022-02-01T00:00:00Z.
• 主题: article
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Idiopathic pulmonary fibrosis (IPF), a severe and deadly form of lung fibrosis, is widely regarded as a disease of aging. We previously demonstrated that aged mice with persistent lung fibrosis and IPF lung myofibroblasts exhibit deficient Nrf2-mediated antioxidant responses. Tecfidera is an orally...