Chloramphenicol Derivatization in Its Primary Hydroxyl Group with Basic Amino Acids Leads to New Pharmacophores with High Antimicrobial Activity

Chloramphenicol Derivatization in Its Primary Hydroxyl Group with Basic Amino Acids Leads to New Pharmacophores with High Antimicrobial Activity

In a previous study published by our group, successful modification of the antibiotic chloramphenicol (CHL) was reported, which was achieved by replacing the dichloroacetyl tail with alpha and beta amino acids, resulting in promising new antibacterial pharmacophores. In this study, CHL was further m...

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Main Authors: Artemis Tsirogianni (Author), Georgia G. Kournoutou (Author), Maria Mpogiatzoglou (Author), George Dinos (Author), Constantinos M. Athanassopoulos (Author)
Format: Book
Published: MDPI AG, 2023-04-01T00:00:00Z.
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